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Urinary metabolites of brominated fatty acids - identification and kinetics in rats

Vidal Eliezer Sotillo

Urinary metabolites of brominated fatty acids - identification and kinetics in rats

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Published .
Written in English

    Subjects:
  • Urine -- Analysis.,
  • Rats.

  • Edition Notes

    Statementby Vidal Eliezer Sotillo.
    The Physical Object
    Pagination[11] 58 leaves, bound :
    Number of Pages58
    ID Numbers
    Open LibraryOL14212709M

    The effects of dietary protein and fat on renal function-related blood and urine parameters, such as albumin, urinary protein,and inflammatory cytokines were investigated in adriamycin- (ADR) induced nephrotic syndrome rats. ADR (2 mg/kg BW) was injected i.p. weekly for six weeks to develop nephrotic syndrome; thereafter rats were fed low-protein/high-fat (LPHF) or high Cited by: 9.   Energy and nutrient metabolism, as the fundamental component of life, supports other bioactivities in humans and animals. Understanding the metabolic status in the whole body, tissue, cells, or subcellular compartments could provide mechanistic insights on the benefits or toxicities caused by specific diets, chemical treatments, and pathophysiological conditions. ALOX12 (EC ), also known as arachidonate lipoxygenase, lipoxygenase, 12S-Lipoxygenase, LOX, and 12S-LOX is a lipoxygenase-type enzyme that in humans is encoded by the ALOX12 gene which is located along with other lipoyxgenases on chromosome 17p ALOX12 is 75 kilodalton protein composed of amino s: ALOX12, LOX, 12S-LOX, LOG12, .


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Urinary metabolites of brominated fatty acids - identification and kinetics in rats by Vidal Eliezer Sotillo Download PDF EPUB FB2

URINARY METABOLITES OF BROMINATED FATTY ACIDS IDENTIFICATION AND KINETICS IN RATS INTRODUCTION Use and Distribution of Brominated Oils Brominated vegetable oils are used in several foods to adjust the density of flavoring oils and to enhance cloud stability in beverages (Jacobs, ).

Being of higher density than normal. Urinary metabolites of brominated fatty acids - identification and kinetics in ratsAuthor: Vidal Eliezer Sotillo. Download PDF: Sorry, we are unable to provide the full text but you may find it at the following location(s): (external link).

Shorter-chain (C, C) metabolites of di- and tetrabromostearate were identified and the concentration of brominated fatty acids in heart, liver and adipose tissue determined and found to account for 80% of Urinary metabolites of brominated fatty acids - identification and kinetics in rats book bromine detected in these tissues by neutron activation by:   Rats dosed orally for four days with g/kg body weight per day of brominated olive oil (BOO) or brominated sesame oil (BSO) were found to accumulate dibromostearic (DBS) acid (from BOO) and DBS and tetrabromosteric (TBS) acids (from BSO) in the liver, heart and adipose tissue.

The metabolites, dibromopalmitic, and dibromomyristic acids (from BOO and Cited by: 9. Thus, as a test of their capacity to oxidize medium- and short-chain fatty acids, two groups of fatty and lean rats were transferred to diets enriched with either trioctanoylglyceride, a medium-chain triglyceride (MCT), or sodium butyrate, a short-chain fatty by: 8.

Metabolic Fate of Dietary Carnitine in Human Adults: Identification and Quantification of Urinary and Fecal Metabolites Article (PDF Available) in Journal of Nutrition (4). (b) The product ion spectra of hydroxy and oxo metabolites excreted in urine from rats dosed with commercial DiDP ( mg/(kg), CAS ).

For the metabolites with carboxylic acid functionalities, product ions corresponding to various fragments (m / z: [C 8 H 15 O] −, [C 7 H 13 O] −, 99 [C 6 H 11 O] −, 85 [C 5 H 9 O] −, and 71 [C 4 Urinary metabolites of brominated fatty acids - identification and kinetics in rats book 7 O] −) were observed in Cited by: With an in-depth metabolic footprinting, a panel of urinary and fecal metabolites were identified as end points of microbial−mammalian co-metabolism, which brings evidence that the gut microbiota modulates the host systemic metabolism involving tryptophan, lipids, amino acids, and possibly a compensatory mechanism of indole Cited by: amour,t of polyunsaturated fatty ac ids (PUFA).

About 20% of the dry weight of the brain constitute essential fatty acids. Hence any change in the relative content of fatty acids may affect cognitive function and be­ haviour Fatty acids incorporated into phospholipids are very important in mai ntaining the structural and.

The tissue distribution and chemical forms of arsenic were compared in two animal species with different metabolic capacity and toxicity to arsenic.

Hamsters and rats were given a single oral dose of arsenite (iAsIII) at mg As/kg body weight, and then the concentrations of arsenic were determined; more than 75% of the dose accumulated in rat red blood cells (RBCs) in the form Cited by: Drug Metabolism and Pharmacokinetics Vol. 5 () No. 2 P Studies on the Metabolic Fate of Azuletil Sodium (I):Identification of the Urinary Metabolites in Male Rats.

Hiroaki SUZAKA 1), Michihiro TAKESHITA 1), Author: Hiroaki Suzaka, Michihiro Takeshita, Masao Sato, Tsuyoshi Tomiyama, Hiroshi Miyazaki. These metabolites are often detected in human urine samples when the catabolism of branched-chain amino acids (BCAA) (especially isoleucine) is impai 71, suggesting that THC.

In this study, urinary metabolites of citral in male F rats were characterized and identified by comparison with synthetic standards of known stereochemistry. Stereospecific oxidation of citral at the C-8 methyl was investigated, as was the hydrolytic sensitivity of biliary and urinary by: The critical Urinary metabolites of brominated fatty acids - identification and kinetics in rats book 2 hydration reaction to bicarbonate and protons is catalyzed by carbonic anhydrases (CAs, EC ).

Their physiological role is to assist the transport of the CO 2 and HCO 3 − at the cellular level, which will not be ensured by the low velocity of the uncatalyzed reaction. CA inhibition may impair the growth of microorganisms.

In the yeasts, Candida. Plasma concentrations of metabolites along the choline oxidation pathway have been linked to increased risk of major lifestyle diseases, and peroxisome proliferator-activated receptors (PPARs) have been suggested to be involved in the regulation of key enzymes along this pathway.

In this study, we investigated the effect of PPAR activation on circulating and urinary one-carbon metabolites Cited by: 8. Rats dosed orally for four days with g/kg body weight per day of brominated olive oil (BOO) or brominated sesame oil (BSO) were found to accumulate dibromostearic (DBS) acid (from BOO) and DBS and tetrabromostearic (TBS) acids (from BSO) in the liver Cited by: 9.

The ability to identify and quantify small molecule metabolites derived from gut microbial–mammalian cometabolism is essential for the understanding of the distinct metabolic functions of the microbiome.

To date, analytical protocols that quantitatively measure a complete panel of microbial metabolites in biological samples have not been established but are Cited by: This book is the result of the 2nd International Symposium on Energy and Protein Metabolism and Nutrition.

It presents the latest results on energy and protein metabolism and nutrition. It is oriented towards livestock science but also addresses general aspects of protein and energy metabolism as applied to animals or biomedical sciences.

JCY Chan, DYQ Kioh, GC Yap, BW Lee, ECY Chan. Targeted LC/MS-based quantitative profiling of 15 gut microbiome-derived short-chain fatty acids in infant and adult stool. 11 th International ISSX MeetingJuneBusan, South Korea. Drug Metabolism and Pharmacokinetics(32) S62, Supp.

Induction of xenobiotic metabolism in rats by brominated diphenyl ethers. The caffeine breath test and caffeine urinary metabolite ratios in the Michigan cohort exposed to polybrominated biphenyls: a preliminary study Uptake of fatty acids by jejunal mucosal cells is mediated by a fatty acid binding membrane protein.

received via dietary sources. There are two classes of essential fatty acids omega-3 and omega-6 (El-Khayat et al., ). Omega-3 fatty acids or ω -3 fatty acids are family of unsaturated fatty acids that have a final carbon- carbon double bond in the 3-position, that is the third bond from the methyl end of the fatty acid.

B) Non nitrogenous organic compounds 1- Carbohydrates: Present in very small undetected amounts eg;- Glucose - pentoses especially after high fruits intake. 2- Lipids: Very small amounts of short chain fatty acids.

3- Organic acids: Mainly glucouronic acid, which present in conjugation with other substances e.g. six hormones. The present research examined the hypothesis that omega-3 polyunsaturated fatty acids would increase seizure threshold in rats in vivo, and reduce neuronal excitability in mouse hippocampal slices.

Seizure thresholds were measured in rats using the maximal pentylenetetrazol and electrical stimulation seizure tests following α-linolenic acid (ALA)Author: Ameer Taha. Stamenkovic A, Ganguly R, Aliani M, Ravandi A and Pierce G, Overcoming the Bitter Taste of Oils Enriched in Fatty Acids to Obtain Their Effects on the G.

C.; Aliani, M., Identification of urinary metabolites with potential blood pressure lowering effects in lentil-fed spontaneously hypertensive rats Michel Aliani, Chibuike C. () Influence of w-3 fatty acids on splanchic blood flow and lactate metabolism in an endotoxemic rat model.

Metabolism (Impact Factor: Ranking: 49 out of 88) (Cited by 24). Wan JMF, Istfan NW, Chu, CC, Blackburn GL, Bistrian BR.

() Comparative effects of w-3 and w-6 polyunsaturated fatty acids on protein. Biological and Pharmaceutical Bulletin, ISSN, Vol Issue 6, pp. -   Kakkalide is a major isoflavonoid from the flowers of Pueraria lobata (Willd.) Ohwi, possessing the protective effect against ethanol-induced intoxication and hepatic injury.

The metabolism of kakkalide was investigated in rats. Chemical Society Reviews, ISSN03/, Vol Issue 6, pp. -   METHODS: Female Sprague-Dawley rats (age 28 d) were randomly assigned (n = 10/group) to be fed a high fat 12% (wt) diet consisting of either corn oil (CO) or n-3 PUFA rich flaxseed (FO), krill (KO), menhaden (MO), salmon (SO) or tuna (TO) oil for 8 by: Currently Chenomx provides sample preparation services for alcohols, fatty acids, amino acids, sugars, organic acids, and nucleic acid components to name a few.

With over compounds in the Chenomx database, metabolomic researchers in need of interpretation of compounds or pathways they study are just a few clicks away from accessing an. Toxicokinetic studies of brominated tri-HAAs indicate that metabolic clearance can account for 40% to 70% of the total body clearance in rats.

9,10 The disposition of a 14 C-BDCAA oral dose in mice is known to be largely converted into 14 CO 2 or 14 C-oxalate. 11 Previous studies using BDCAA suggested that metabolism is primarily microsomal Cited by: 1. Data on the cumulative excretion of iAs and its methylated metabolites in urine is given in Table h cumulative amount of total arsenic (inorganic + organic arsenic) excreted was ± μg/kg body weight (BW) in control animals, ± μg/kg BW in 10 μmole As/kg-treated animals, and ± μg/kg BW in μmole As/kg-treated by: Effect of fatty acids on the permeation of melatonin across rat and pig skin in-vitro and on the transepidermal water loss in rats in-vivo Kandimalla, K., Kanikkannan, N., Andega, S.

& Singh, M., JulIn: Journal of Pharmacy and Pharmacology. 51, 7, p. 8 p. Research output: Contribution to journal › Article. Trichloroacetic acid (TCA) (Final, ) The mg/kg dose group was used to calibrate the PBPK model for TCE and its metabolites. Urinary excretion rate constant values were 0.

06/hr/kg for CH, /hr/kg for TCOH, /hr/kg for TCOG, and 1. 55/hr/kg for TCA. showing that products of lipid metabolism such as fatty acids. Overview of branched chain amino acids metabolism and regulation.

Branched chain amino acids (BCAAs), leucine, isoleucine and valine, are three of the nine essential amino acids and account for 35–40% of the dietary indispensable amino acids in body protein and 14% of the total amino acids in skeletal by:   Non-alcoholic beverages are important sources of nutrients and bioactive compounds that may influence human health and increase or decrease the risk of chronic diseases.

A wide variety of beverage constituents are absorbed in the gut, found in the systemic circulation and excreted in urine. They may be used as compliance markers in intervention Cited by: 9. labeled metabolites, we have simultaneously studied biliary and urinary excretion of tritium-labeled compounds after the infu- sion of nL-epinephrineH3-n-bitartrate.1 EXPERIMENTAL PROCEDURE Male Sprague-Dawley rats weighing to g were anes- thetized by intraperitoneal injection of urethane ( g per kg).

The dose dependence of the urinary excretion of acrylonitrile (ACN) metabolites was studied after oral administration of [2,C]ACN to male F rats ( to mg/kg) and male B6C3F1 mice ( to mg/kg). Urine was the major route of excretion of ACN metabolites (77 to % of the dose), with less than 8% of the dose excreted in the by: It has a role as an EC (triacylglycerol lipase) inhibitor, a bacterial metabolite, an EC (fatty acid synthase) inhibitor and an anti-obesity agent.

It is a beta-lactone, a L-leucine derivative, a member of formamides and a carboxylic ester. Long-chain fatty acids must be esterified to L-carnitine (acylcarnitine) in order to pdf the mitochondrial matrix where β-oxidation occurs (Figure 3). On the outer mitochondrial membrane, CPTI (carnitine-palmitoyl transferase I) catalyzes the transfer of medium/long-chain fatty acids esterified to coenzyme A (CoA) to L-carnitine.Male Sprague-Dawley-rats were exposed to 50,or parts per million download pdf carbon-disulfide for 6 hours each day, 5 days a week, over a 6 month period.

In selected rats, urine was collected over a period of 8 to 16, 16 to 24, and 24 to 48 hours following the last exposure. The elimination of urinary TTCA followed pseudo first order kinetics.Fatty ebook, tall-oil, compds.

with triethanolamine. EC number: | CAS number: Oleic acid used as a ebook control (a fatty acid that is safely used as a food additive). Tested at 5 and 10 % (by weight) in the diet An aliquot of the urine was removed by the technologist and, if found contaminated with faecal.